Making magnetic biomaterials
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Researchers have developed silk iron microparticles (SIMPs) — magnetic, biodegradable carriers designed to deliver therapies directly to disease sites like aneurysms or tumors. The particles are created by chemically bonding iron oxide nanoparticles to regenerated silk fibroin using glutathione, enhancing their magnetic responsiveness while maintaining biocompatibility. These nanoscale carriers, roughly one-hundred-thousandth the width of a human hair, can potentially be guided externally to precise locations in the body. The platform enables localized delivery of therapeutic agents such as extracellular vesicles, regenerative factors, or drugs, offering a minimally invasive approach to treating conditions like abdominal aortic aneurysms and expanding the potential for targeted therapies in regenerative medicine.
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